Background: In patients with diabetes mellitus, the urinary microalbumin-to-urine creatinine ratio (UACR) can not\nonly predict the occurrence of diabetic nephropathy but also can be a risk factor for cardiovascular disease and renal\nfunction damage. Current studies on subclinical hypothyroidism (SCH) and UACR are mainly cross-sectional studies, and\nthe results suggest that SCH is an independent risk factor for UACR. To further explore the longitudinal effect of SCH on\nUACR, we carried out this study.\nMethods: This was a retrospective cohort study including 46 patients with type 2 diabetes mellitus and SCH in the\nDepartment of Endocrinology, The Affiliated Huaiâ??an Hospital of Xuzhou Medical University from January 2013 to April\n2018. At the same time, 96 patients with type 2 diabetes mellitus and euthyroid were chosen according to 1:2\napproximately matched with age, sex and duration of diabetes mellitus. Univariate analysis, stratified analysis, and\nmultiple linear regression analysis were used to investigate the effect of SCH on DELTA UACR(DELTAUACR = UACR after 1 year -\nbaseline UACR) in patients with type 2 diabetes mellitus.\nResults: There was no significant difference between the baseline UACR, (p > 0.05). However, the DELTAUACR was significantly\nhigher in SCH group than euthyroid group, as shown by univariate analysis, stratified analysis and multiple linear regression\nanalysis (Beta:-1.071, 95% CI: - 1.713-0.428), and the difference was statistically significant (all p<0.05).\nConclusion: SCH is associated with an increased UACR in type 2 diabetes mellitus patients. It is necessary to screen for\nthyroid function in type 2 diabetes mellitus and increase the follow-up frequency of UACR in patients with SCH.
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